巨噬清除

PBS Liposomes（Blank）

PBS Liposomes（Blank )空脂质体，作为Clodronate Liposomes的严格对照，通过与Clodronate Liposomes相同的机制被单核细胞/巨噬细胞识别和吞噬。由于对照脂质体不含氯膦酸盐，因此单核细胞/巨噬细胞不会被清除。然而，单核细胞/巨噬细胞确实/可能通过细胞因子分泌、吞噬活性的暂时中止和文献中描述的其他反应来对因PBS Liposomes对照脂质体的摄入产生反应。

PBS Liposomes(Blank) are formulated and prepared identically to Clodronate Liposomes except that clodronate is not added to the liposomes. PBS Liposomes(Blank) are recognized and phagocytosed by the same mechanism as Clodronate Liposomes.However, phagocytes do respond to the ingestion of control liposomes by cytokine secretion, temporary suspension of phagocytic activity and other responses described in the literature.

Highlights:

* Reduce the background values of the experimental and control groups

* The most ideal and rigorous control relative to PBS, etc

货号 品名 规格 库存 价格
CLD-8910-2ml
 PBS Liposomes(Blank) 2ml in stock 1500.0
CLD-8910-5ml
 PBS Liposomes(Blank) 5ml in stock 2900.0
CLD-8910-10ml
 PBS Liposomes(Blank) 10ml in stock 5500.0
CLD-8910-15ml
 PBS Liposomes(Blank) 15ml in stock 7500.0
CLD-8910-20ml
 PBS Liposomes(Blank) 20ml in stock 10000.0
CLD-8910-25ml
 PBS Liposomes(Blank) 25ml in stock 13000.0
产品详情

品类型/Product Type:Chemicals
产品名称/Name:PBS Liposomes(Blank)
脂质构成/Lipid Composition:Cholesterol, L-alpha-Phosphatidylcholine
包裹药物/Encapsulated Drug:None
外观形态/Format:White milky suspensions
缓冲液/Buffer: Phosphate buffered saline (20 mM sodium phosphate, 0.9 % NaCl)
PH值/PH: 7.0-7.5
保存期/Shelf Life3 months guaranteed for unopened vials at 2-8 ºC
注意事项/Comments: Liposomes should be kept at 2-8°C and NEVER be frozen
存储温度/Storage: Upon receipt store at 2-8℃
运输温度/Shipped:Ice pack  

文档资料

PDF-logo Technical-Information-for-PBS Liposomes

产品源头

Country of origin: USA

参考文献

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  2. van Rooijen N, van Nieuwmegen R, Kamperdijk EW. Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. Ultrastructural aspects of elimination of marginal zone macrophages. Virchows Arch B Cell Pathol Incl Mol Pathol. 1985;49(4):375-83. doi: 10.1007/BF02912114. PMID: 2867636. View Article

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  4. van Rooijen N, Kors N, ter Hart H, Claassen E. In vitro and in vivo elimination of macrophage tumor cells using liposome-encapsulated dichloromethylene diphosphonate. Virchows Arch B Cell Pathol Incl Mol Pathol. 1988;54(4):241-5. doi: 10.1007/BF02899217. PMID: 2895535. View Article

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  7. Su D, Van Rooijen N. The role of macrophages in the immunoadjuvant action of liposomes: effects of elimination of splenic macrophages on the immune response against intravenously injected liposome-associated albumin antigen. Immunology. 1989 Mar;66(3):466-70. PMID: 2703258; PMCID: PMC1385238.  View Article

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  59. Bayón LG, Izquierdo MA, Sirovich I, van Rooijen N, Beelen RH, Meijer S. Role of Kupffer cells in arresting circulating tumor cells and controlling metastatic growth in the liver. Hepatology. 1996 May;23(5):1224-31. doi: 10.1002/hep.510230542. PMID: 8621157. View article

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  62. van Rooijen N, Sanders A, van den Berg TK. Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine. J Immunol Methods. 1996 Jun 14;193(1):93-9. doi: 10.1016/0022-1759(96)00056-7. PMID: 8690935. View article

  63. Gaytan F, Bellido C, Morales C, García M, van Rooijen N, Aguilar E. In vivo manipulation (depletion versus activation) of testicular macrophages: central and local effects. J Endocrinol. 1996 Jul;150(1):57-65. doi: 10.1677/joe.0.1500057. PMID: 8708563. View article

  64. Karupiah G, Buller RM, Van Rooijen N, Duarte CJ, Chen J. Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection. J Virol. 1996 Dec;70(12):8301-9. doi: 10.1128/JVI.70.12.8301-8309.1996. PMID: 8970949; PMCID: PMC190917. View article

  65. de Haan A, Groen G, Prop J, van Rooijen N, Wilschut J. Mucosal immunoadjuvant activity of liposomes: role of alveolar macrophages. Immunology. 1996 Dec;89(4):488-93. doi: 10.1046/j.1365-2567.1996.d01-787.x. PMID: 9014811; PMCID: PMC1456575. View article

  66. Wolff G, Worgall S, van Rooijen N, Song WR, Harvey BG, Crystal RG. Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ. J Virol. 1997 Jan;71(1):624-9. doi: 10.1128/JVI.71.1.624-629.1997. PMID: 8985392; PMCID: PMC191093.. View article

  67. van Rooijen N, Sanders A. Elimination, blocking, and activation of macrophages: three of a kind? J Leukoc Biol. 1997 Dec;62(6):702-9. doi: 10.1002/jlb.62.6.702. PMID: 9400810. View article