巨噬清除

Clodronate Liposomes

Clodronate Liposomes：氯膦酸二钠脂质体，是包裹有清除单核/巨噬细胞活性成分氯膦酸二钠的多层脂质体悬浮液。Clodronate Liposomes被单核细胞/巨噬细胞识别和吞噬，利用特洛伊木马机制Torjan Horse，脂质体包裹的氯膦酸二钠得以释放到细胞质中，当蓄积到阈浓度，导致吞噬细胞凋亡，从而清除吞噬细胞。

Clodrosome® is a multilamellar liposome suspension in which clodronate is encapsulated in the aqueous compartments of the liposomes. The negatively-charged clodronate liposomes, offers superior efficiency of macrophage depletion. Clodronate molecules are encapsulated in LUV liposomes for superior activity, physical and chemical stability, and convenience of use.

Highlights:

* Good consistency in macrophage depletion 

* Suitable for dosing with various routes including intravenous, intraperitoneal, subcutaneous, intranasal, intratracheal and etc. 


货号 品名 规格 库存 价格
CLD-8909-2ml
 Macrophage Depletion Reagents ClodronateLiposomes 2ml in stock 2980.0
CLD-8909-5ml
 Macrophage Depletion Reagents ClodronateLiposomes 5ml in stock 5980.0
CLD-8909-10ml
 Macrophage Depletion Reagents ClodronateLiposomes 10ml in stock 9980.0
CLD-8909-15ml
 Macrophage Depletion Reagents ClodronateLiposomes 15ml in stock 13980.0
CLD-8909-20ml
 Macrophage Depletion Reagents ClodronateLiposomes 20ml in stock 17980.0
CLD-8909-25ml
 Macrophage Depletion Reagents ClodronateLiposomes 25ml in stock 21980.0
产品详情

品类型/Product Type:Chemicals
产品名称/Name:Clodronate Liposomes
脂质构成/Lipid Composition:Cholesterol, L-alpha-Phosphatidylcholine
包裹药物/Encapsulated Drug:Clodronate disodium
外观形态/Format:White milky suspensions
缓冲液/Buffer: Phosphate buffered saline (20 mM sodium phosphate, 0.9 % NaCl)
PH值/PH: 7.0-7.5
保存期/Shelf Life：3 months guaranteed for unopened vials at 2-8 ºC
注意事项/Comments: Liposomes should be kept at 2-8°C and NEVER be frozen
存储温度/Storage: Upon receipt store at 2-8℃
运输温度/Shipped:Ice pack  

文档资料

PDF-logo Technical-Information-for-Clodronate Liposomes

产品源头

Country of origin: USA

参考文献

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  66. Wolff G, Worgall S, van Rooijen N, Song WR, Harvey BG, Crystal RG. Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ. J Virol. 1997 Jan;71(1):624-9. doi: 10.1128/JVI.71.1.624-629.1997. PMID: 8985392; PMCID: PMC191093.. View article

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